Beilstein J. Org. Chem.2019,15, 2184–2190, doi:10.3762/bjoc.15.215
synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly controlled carbocationic chemistry of this sesquiterpene cyclase.
Keywords: artemisinin; amorphadiene synthase; oxygenatedterpenoids; sesquiterpenoids; substrate
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Graphical Abstract
Scheme 1:
Mechanism of the ADS-catalysed conversion of FDP (2) to amorpha-4,11-diene (3), a biosynthetic prec...